| Reaction Details |
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 | Report a problem with these data |
| Target | Ataxin-1 |
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| Ligand | BDBM579837 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical ATX Assa |
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| IC50 | 2.00±n/a nM |
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| Citation |  Kuttruff, CA; Bretschneider, T; Godbout, C; Koolman, HF; Martyres, D; Roth, GJ N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators US Patent US11485727 Publication Date 11/1/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ataxin-1 |
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| Name: | Ataxin-1 |
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| Synonyms: | ATX1 | ATX1_HUMAN | ATXN1 | SCA1 |
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| Type: | Protein |
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| Mol. Mass.: | 86941.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P54253 |
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| Residue: | 815 |
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| Sequence: | MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRH
GPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQY
AHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTL
LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPP
PAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHF
VPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRH
VVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGK
PGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQ
HLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVT
QAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQ
SAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSC
CPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSR
HRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESR
KLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
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| BDBM579837 |
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| n/a |
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| Name | BDBM579837 |
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| Synonyms: | US11485727, Example 2.8 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27F3N6O2 |
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| Mol. Mass. | 500.5161 |
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| SMILES | FC(F)(F)c1ccc(COc2ccc(NCc3ccc(cc3)N3CCN(CC3)C3COC3)nn2)cn1 |
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| Structure | 
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