| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] |
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| Ligand | BDBM482186 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PERK enzyme assays |
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| IC50 | <16±n/a nM |
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| Citation |  Bindi, S; Carenzi, D; Motto, I; Pulici, M N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors US Patent US11491158 Publication Date 11/8/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] |
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| Name: | Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] |
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| Synonyms: | E2AK3_HUMAN | EIF2AK3 | PEK | PERK |
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| Type: | Enzyme |
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| Mol. Mass.: | 65443.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NZJ5 [540-1115] |
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| Residue: | 576 |
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| Sequence: | VRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCL
GRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWL
EAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRS
RSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGN
DEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTA
FKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDW
MNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLV
TAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLY
PFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFED
LDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPS
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| BDBM482186 |
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| n/a |
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| Name | BDBM482186 |
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| Synonyms: | 2,3-Dihydro-benzofuran-5-sulfonic acid [3-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-fluoro-phenyl]-amide | US10918642, Cmpd # 27 | US11491158, Cmpd 27 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18FN5O3S |
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| Mol. Mass. | 439.463 |
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| SMILES | Cn1cc(-c2cccc(NS(=O)(=O)c3ccc4OCCc4c3)c2F)c2c(N)ncnc12 |
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| Structure | 
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