| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
|---|
| Ligand | BDBM581311 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition of MTHFD2 |
|---|
| IC50 | 44.0±n/a nM |
|---|
| Citation |  Bengtsson, C; Borhade, S; Haraldsson, M; Helleday, T; Henriksson, M; Homan, E; Paulin, C; Sandberg, L; Scobie, M; Stenmark, P; Vallin, K 2,6-diamino-3,4-dihydropyrimidin-4-one derivatives and use thereof in therapy US Patent US11504368 Publication Date 11/22/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
|---|
| Name: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
|---|
| Synonyms: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | MTDC_HUMAN | MTHFD2 | Methenyltetrahydrofolate cyclohydrolase | NAD-dependent methylenetetrahydrofolate dehydrogenase | NMDMC |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 37904.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_109900 |
|---|
| Residue: | 350 |
|---|
| Sequence: | MAATSLMSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEW
VASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKL
NNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGV
WEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQL
KKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQ
KAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN
|
|
|
|---|
| BDBM581311 |
|---|
| n/a |
|---|
| Name | BDBM581311 |
|---|
| Synonyms: | (2S)-2-({5-[2-(2,4-diamino-6-oxo- 1,6-dihydropyrimidin-5- yl)acetamido]-6-methoxypyridin-2- yl}formamido)pentanedioic acid | US11504368, Example 29 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H21N7O8 |
|---|
| Mol. Mass. | 463.4014 |
|---|
| SMILES | COc1nc(ccc1NC(=O)Cc1c(N)nc(N)[nH]c1=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
