Ki Summary

Reaction Details

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Target

Monoglyceride lipase

Ligand

BDBM581596

Substrate/Competitor

n/a

Meas. Tech.

Biological Assay

IC50

0.082±n/a nM

Citation

Alcazar, J; Ameriks, MK; Berry, CB; Garcia-Reynaga, P; Samant, AV; Vega-Ramiro, JA Azaspirocycles as monoacylglycerol lipase modulators US Patent US11505546 Publication Date 11/22/2022

More Info.:

Get all data from this article, Assay Method

Monoglyceride lipase

Name:

Monoglyceride lipase

Synonyms:

Type:

Hydrolase

Mol. Mass.:

33264.56

Organism:

Homo sapiens (Human)

Description:

Human recombinant MGL (Cayman Chemical, cat# 10008354).

Residue:

303

Sequence:

MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP

BDBM581596

n/a

Name

BDBM581596

Synonyms:

(2r,4s)-2-(2-(3-(tert-Butyl)phenyl)-7-azaspiro[3.5]nonane-7-carbonyl)-5- azaspiro[3.4]octan-6-one | US11505546, Example 11

Type

Small organic molecule

Emp. Form.

C26H36N2O2

Mol. Mass.

408.5762

SMILES

CC(C)(C)c1cccc(c1)C1CC2(C1)CCN(CC2)C(=O)[C@H]1C[C@@]2(C1)CCC(=O)N2 |r,wU:21.23,wD:23.26,(9.82,-1.7,;8.48,-.93,;8.48,.61,;9.82,-.16,;7.15,-1.7,;7.15,-3.24,;5.82,-4.01,;4.48,-3.24,;4.48,-1.7,;5.82,-.93,;3.15,-.93,;1.66,-1.33,;1.26,.16,;2.75,.56,;-.07,-.61,;-1.41,.16,;-1.41,1.7,;-.07,2.47,;1.26,1.7,;-2.74,2.47,;-2.74,4.01,;-4.07,1.7,;-4.47,.21,;-5.96,.61,;-5.56,2.1,;-5.96,-.93,;-7.42,-1.41,;-8.33,-.16,;-9.82,.24,;-7.42,1.09,)|

Structure