Reaction Details |
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Target | Leukotriene C4 synthase |
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Ligand | BDBM223288 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro hLTC4 Synthase Enzyme Assay |
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IC50 | 0.248±n/a nM |
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Citation | Ronn, R; Lindh, CJ; Ringberg, E; Andersson, HB; Nilsson, P; Schaal, WR; Munck af Rosenschöld, M; Nikitidis, A; Nikitidis, G; Johannesson, P; Tyrchan, C Compounds and uses US Patent US9657001 Publication Date 5/23/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Leukotriene C4 synthase |
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Name: | Leukotriene C4 synthase |
Synonyms: | LTC4 synthase | LTC4S | LTC4S_HUMAN | Leukotriene-C(4) synthase |
Type: | PROTEIN |
Mol. Mass.: | 16575.59 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_961179 |
Residue: | 150 |
Sequence: | MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYF
PLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVA
LAALGLLAHFLPAALRAALLGRLRTLLPWA
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BDBM223288 |
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n/a |
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Name | BDBM223288 |
Synonyms: | (1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-5-(trifluoromethyl)phenyl]amino}-3-methoxypyrazin-2-yl)carbonyl]cyclopropanecarboxylic acid | US20160326143, 63 | US9657001, 63 |
Type | Small Organic Molecule |
Emp. Form. | C21H20F5N3O4 |
Mol. Mass. | 473.3932 |
SMILES | COc1nc(cnc1C(=O)[C@H]1C[C@@H]1C(O)=O)N(CC(C)(C)F)c1cc(ccc1F)C(F)(F)F |
Structure |
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