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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone-lysine N-methyltransferase EZH1 | ||
| Ligand | BDBM588045 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibitory Activity Assay | ||
| IC50 | 32.0±n/a nM | ||
| Citation |  Jung, SH; Hong, DJ; Hwang, JY; Kim, SH; Park, SM; Mah, SM; Ahn, YG Dioxoloisoquinolinone derivatives and use thereof US Patent US11535629 Publication Date 12/27/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone-lysine N-methyltransferase EZH1 | |||
| Name: | Histone-lysine N-methyltransferase EZH1 | ||
| Synonyms: | ENX-2 | EZH1 | EZH1_HUMAN | Enhancer of zeste homolog 1 | Enhancer of zeste homolog 1 (EZH1) | Histone-lysine N-methyltransferase EZH1 | KIAA0388 | ||
| Type: | Protein | ||
| Mol. Mass.: | 85285.34 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q92800 | ||
| Residue: | 747 | ||
| Sequence: |
| ||
| BDBM588045 | |||
| n/a | |||
| Name | BDBM588045 | ||
| Synonyms: | (R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)methyl)-2- (trans-4- (dimethylamino)cyclohexyl)-2,4- dimethyl-9-(pyridin-4-yl)-7,8- dihydro-[1,3]dioxolo[4,5- g]isoquinolin-5(6H)-one | US11535629, Compound 34 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C33H40N4O4 | ||
| Mol. Mass. | 556.6951 | ||
| SMILES | CN(C)[C@H]1CC[C@@H](CC1)[C@]1(C)Oc2c(O1)c(-c1ccncc1)c1CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c1c2C |r,wU:9.10,3.2,wD:6.6,(10.3,1.64,;8.9,2.26,;8.74,3.8,;7.65,1.36,;7.81,-.17,;6.57,-1.08,;5.16,-.45,;5,1.08,;6.24,1.99,;4.07,-1.54,;5.16,-2.63,;3.16,-2.79,;1.7,-2.31,;1.7,-.77,;3.16,-.29,;.37,,;.37,1.54,;1.7,2.31,;1.7,3.85,;.37,4.62,;-.97,3.85,;-.97,2.31,;-.97,-.77,;-2.3,,;-3.63,-.77,;-3.63,-2.31,;-4.97,-3.08,;-6.3,-2.31,;-7.64,-3.08,;-7.64,-4.62,;-8.97,-2.31,;-8.97,-.77,;-10.3,,;-7.64,,;-6.3,-.77,;-4.97,,;-2.3,-3.08,;-2.3,-4.62,;-.97,-2.31,;.37,-3.08,;.37,-4.62,)| | ||
| Structure | 
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