| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit gamma-1 |
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| Ligand | BDBM586078 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Steroid Inhibition of TBPS Binding |
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| IC50 | <10±n/a nM |
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| Citation |  Martinez Botella, G; Salituro, FG; Robichaud, AJ; Harrison, BL Compositions and methods for treating CNS disorders US Patent US11542297 Publication Date 1/3/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-aminobutyric acid receptor subunit gamma-1 |
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| Name: | Gamma-aminobutyric acid receptor subunit gamma-1 |
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| Synonyms: | Benzodiazepine receptors | Benzodiazepine receptors; peripheral & central | GABA receptor gamma-1 subunit | GBRG1_RAT | Gabrg1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53557.84 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_193817 |
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| Residue: | 465 |
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| Sequence: | MGSGKVFLFSPSLLWSQTRGVRLIFLLLTLHLGNCIDKADDEDDEDLTMNKTWVLAPKIH
EGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWF
DSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWSDGRVLYTL
RLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAF
VGLRNSTEISHTISGDYIIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVP
ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSN
NKGKTTRDRKLKSKTSVSPGLHAGSTLIPMNNISMPQGEDDYGYQCLEGKDCATFFCCFE
DCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
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| BDBM586078 |
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| n/a |
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| Name | BDBM586078 |
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| Synonyms: | US11530237, Compound 259 | US11542297, Compound 259 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H37FN2O2 |
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| Mol. Mass. | 416.5719 |
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| SMILES | C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)Cn1cnc(F)c1 |r| |
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| Structure | 
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