Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM593769

Substrate/Competitor

n/a

Meas. Tech.

Binding Inhibition for Dopamine D3 Receptor

0.083±n/a nM

Citation

Tobinaga, H; Masuda, K Condensed ring compounds having dopamine D3 receptor antagonistic effect US Patent US11578084 Publication Date 2/14/2023

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

DRD3 | DRD3_HUMAN | Dopamine D3 receptor

Type:

PROTEIN

Mol. Mass.:

44213.40

Organism:

Homo sapiens

Description:

ChEMBL_105671

Residue:

400

Sequence:

MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM593769

n/a

Name

BDBM593769

Synonyms:

US11578084, Compound I-052

Type

Small organic molecule

Emp. Form.

C24H34F2N4O3S

Mol. Mass.

496.614

SMILES

Cc1cc(CC(=O)N[C@H]2CC[C@H](CCN3CCc4nc(OCC(C)(F)F)sc4CC3)CC2)on1 |r,wU:11.11,wD:8.7,(12.95,2.77,;11.41,2.77,;10.5,4.02,;9.04,3.54,;7.7,4.31,;6.37,3.54,;6.37,2,;5.04,4.31,;3.7,3.54,;2.37,4.31,;1.04,3.54,;1.04,2,;-.3,1.23,;-1.63,2,;-2.97,1.23,;-4.32,1.96,;-5.74,1.36,;-6.15,-.19,;-7.61,-.67,;-7.61,-2.21,;-8.95,-2.98,;-10.28,-2.21,;-11.61,-2.98,;-12.95,-2.21,;-12.38,-4.31,;-10.84,-4.31,;-6.15,-2.69,;-5.24,-1.44,;-3.7,-1.44,;-2.69,-.28,;2.37,1.23,;3.7,2,;9.04,2,;10.5,1.53,)|

Structure