| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Ligand | BDBM469007 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LOX Enzyme Activity Assay |
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| IC50 | 300±n/a nM |
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| Citation |  Springer, C; Marais, R; Niculescu-Duvaz, D; Leung, L; Smithen, D; Callens, C; Tang, H Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer US Patent US11608330 Publication Date 3/21/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Synonyms: | 12-LOX | 12/15-lipoxygenase | 15-LOX | ALOX15 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, leukocyte-type | Arachidonate omega-6 lipoxygenase | Erythroid cell-specific 15-lipoxygenase | LOX15_PIG |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74999.86 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_1510008 |
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| Residue: | 663 |
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| Sequence: | MGLYRVRVSTGSSFYAGSQNQVQLWLVGQHGEAALGWCLRPARGKETEFSVDVSEYLGPL
LFVKLRKRHLLQDDAWFCNWISVQGPGANGDEFRFPCYRWVEGDRILSLPEGTARTVVDD
PQGLFKKHREEELAERRKLYRWGNWKDGLILNIASTGIHDLPVDERFLEDKRIDFEASLA
KGLADLAVKDSLNVLMSWNSLDSFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGTNPM
LLRHSVELPARLKFPPGMEELQAQLEKELQGGTLFEADFSLLDGIKANVILCSQQYLAVP
LVMLKLQPDGKLLPMVIQLQLPHEGSPLPPLFLPTDPPMVWLLAKCWVRSSDFQLHELHS
HLLRGHLMAEVIAVATMRCLPSIHPIFKLLIPHFRYTMEINVRARNGLVSDLGIFDQVVS
TGGGGHVELLRRAAALLTYSSFCPPDDLADRGLLGVESSFYAQDALRLWEVISRYVEGIV
SLHYKTDESVKEDLELQAWCREFTEIGLLGAQDRGFPVSLQSKEQLCHFVTMCIFTCTGQ
HSSNHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRC
QPTMVALGQHEEEYFSGPGPKAVLTKFREELAALDKDIEVRNAKLALPYEYLRPSRVENS
VAI
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| BDBM469007 |
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| n/a |
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| Name | BDBM469007 |
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| Synonyms: | US10807974, Example 16 | US10995088, Example 16 | US11608330, Example 16 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H15NO5S3 |
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| Mol. Mass. | 361.457 |
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| SMILES | NCc1ccc(s1)S(=O)(=O)c1ccc(cc1)S(=O)(=O)CCO |
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| Structure | 
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