Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM310353

Substrate/Competitor

n/a

Meas. Tech.

[35S]GTPgammaS Binding

EC50

210±n/a nM

Citation

Chen, X; Cheng, AC; Connors, RV; Debenedetto, MV; Dransfield, PJ; Fu, Z; Harvey, JS; Heath, JA; Houze, J; Judd, TC; Kopecky, DJ; Lai, S; Ma, Z; Nishimura, N; Olson, SH; Pattaropong, V; Wang, X Compounds for use in preparing heterocyclic triazole agonists of the APJ receptor US Patent US10150760 Publication Date 12/11/2018

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM310353

n/a

Name

BDBM310353

Synonyms:

US10150760, Example 173.0 | US10150760, Example 174.0

Type

Small organic molecule

Emp. Form.

C23H27N7O5S

Mol. Mass.

513.569

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(cn2)C#N)nnc1[C@H]1CCOC1 |r,wU:16.17,18.19,wD:31.33,(-8.09,6.51,;-6.76,5.74,;-5.42,6.51,;-5.42,8.05,;-4.09,8.82,;-2.76,8.05,;-2.76,6.51,;-1.42,5.74,;-.09,6.51,;-4.09,5.74,;-4.09,4.2,;-2.84,3.3,;-1.51,4.07,;-.18,3.3,;-.95,1.96,;.59,1.96,;1.16,4.07,;1.16,5.61,;2.49,3.3,;2.49,1.76,;3.83,4.07,;5.16,3.3,;6.49,4.07,;6.54,5.63,;5.16,6.38,;3.83,5.61,;7.87,6.4,;9.21,7.17,;-3.32,1.83,;-4.86,1.83,;-5.33,3.3,;-6.67,4.07,;-7.3,5.38,;-8.68,5.53,;-9.16,4.07,;-7.91,3.16,)|

Structure