| Reaction Details |
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 | Report a problem with these data |
| Target | Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] |
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| Ligand | BDBM497335 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assays for IDH1 and IDH2 Mutant Enzymes |
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| IC50 | 36.9±n/a nM |
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| Citation |  Bauer, RA; Boulet, SL; Burkholder, TP; Gilmour, R; Hahn, PJ; Rankovic, Z 7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors US Patent US11629156 Publication Date 4/18/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] |
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| Name: | Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] |
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| Synonyms: | IDH2 | IDHP_HUMAN | Isocitrate dehydrogenase 2 mutant (R140Q) |
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| Type: | Protein |
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| Mol. Mass.: | 50894.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | R140Q mutant |
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| Residue: | 452 |
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| Sequence: | MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIQNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
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| BDBM497335 |
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| n/a |
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| Name | BDBM497335 |
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| Synonyms: | 7-[[(1S)-1-[4-[(1S)-2- cyclopropyl-1-(4-prop-2- enoylpiperazin-1-yl) ethyl]phenyl]ethyl]amino]- 1-ethyl-4H-pyrimido[4,5- d][1,3]oxazin-2-one | US11001596, Example 2 | US11629156, Example 2 | US11649247, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36N6O3 |
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| Mol. Mass. | 504.6238 |
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| SMILES | CCN1C(=O)OCc2cnc(N[C@@H](C)c3ccc(cc3)[C@H](CC3CC3)N3CCN(CC3)C(=O)C=C)nc12 |r| |
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| Structure | 
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