Reaction Details |
| Report a problem with these data |
Target | Cholinesterase |
---|
Ligand | BDBM9074 |
---|
Substrate/Competitor | BDBM8978 |
---|
Meas. Tech. | Cholinesterase Inhibition Assay |
---|
pH | 8±n/a |
---|
Temperature | 310.15±n/a K |
---|
IC50 | 4700±100 nM |
---|
Citation | Rampa, A; Bisi, A; Belluti, F; Gobbi, S; Valenti, P; Andrisano, V; Cavrini, V; Cavalli, A; Recanatini, M Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives. Bioorg Med Chem8:497-506 (2000) [PubMed] Article |
---|
More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
---|
|
Cholinesterase |
---|
Name: | Cholinesterase |
Synonyms: | Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase |
Type: | Homotetramer |
Mol. Mass.: | 68422.27 |
Organism: | Homo sapiens (Human) |
Description: | P06276 |
Residue: | 602 |
Sequence: | MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
|
|
|
BDBM9074 |
---|
BDBM8978 |
---|
Name | BDBM9074 |
Synonyms: | 10H-indeno[1,2-b]quinolin-11-amine | 11H-indeno-[1,2-b]-quinolin-10-ylamine deriv. 1a | CHEMBL60167 |
Type | Small organic molecule |
Emp. Form. | C16H12N2 |
Mol. Mass. | 232.2799 |
SMILES | Nc1c2Cc3ccccc3-c2nc2ccccc12 |
Structure |
|