| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 2 |
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| Ligand | BDBM310922 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay Data on TC-PTP |
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| IC50 | 1500±n/a nM |
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| Citation |  Tremblay, ML; Penafuerte, C; Feldhammer, M; Zogopoulos, G; Black, C; Kennedy, B TC-PTP inhibitors as APC activators for immunotherapy US Patent US10150787 Publication Date 12/11/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 2 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 2 |
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| Synonyms: | PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP) |
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| Type: | Protein |
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| Mol. Mass.: | 48481.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P17706 |
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| Residue: | 415 |
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| Sequence: | MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVK
LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
VKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTW
PDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD
DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA
FDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKAT
TAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
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| BDBM310922 |
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| n/a |
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| Name | BDBM310922 |
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| Synonyms: | ((6-Bromo-2-(Hydroxymethyl)Benzo[b]Thiophen-5-yl)Difluoromethyl)Phosphonate | US10150787, Example 5 | US11597739, Example 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H8BrF2O4PS |
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| Mol. Mass. | 373.108 |
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| SMILES | OCc1cc2cc(c(Br)cc2s1)C(F)(F)P(O)(O)=O |
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| Structure | 
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