| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium channel subfamily K member 2 |
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| Ligand | BDBM533136 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LMPTP Primary Screening Protocol |
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| IC50 | 500±n/a nM |
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| Citation |  Bottini, N; Zou, J; Ganji, SR; Stanford, S; Pinkerton, A; Chung, TD; Hedrick, M; Ardecky, R Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof US Patent US10626094 Publication Date 4/21/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium channel subfamily K member 2 |
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| Name: | Potassium channel subfamily K member 2 |
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| Synonyms: | KCNK2 | KCNK2_HUMAN | Outward rectifying potassium channel protein TREK-1 | TREK | TREK-1 K(+) channel subunit | TREK1 | Twik-RElated Potassium (K+) channel 1 (TREK1) | Two pore domain potassium channel TREK-1 | Two pore potassium channel TPKC1 |
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| Type: | Protein |
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| Mol. Mass.: | 47099.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O95069 |
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| Residue: | 426 |
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| Sequence: | MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWK
TVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQ
IVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALL
GIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVAL
PAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYF
AAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS
IKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIA
VIENIK
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| BDBM533136 |
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| n/a |
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| Name | BDBM533136 |
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| Synonyms: | N-[2-(dimethylamino)ethyl](4-{4-[(3- piperidylpropyl)amino](2- quinolyl)}phenyl)carboxamide | US10626094, Example I66 | US11220486, Compound I66 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H37N5O |
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| Mol. Mass. | 459.6263 |
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| SMILES | CN(C)CCNC(=O)c1ccc(cc1)-c1cc(NCCCC2CCCNC2)c2ccccc2n1 |
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| Structure | 
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