| Reaction Details |
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 | Report a problem with these data |
| Target | Furin [108-574] |
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| Ligand | BDBM621364 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Furin Enzyme Assay |
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| IC50 | 0.040±n/a nM |
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| Citation |  Axten, JM; Cheung, M; Demartino, MP; Guan, HA; Hu, Y; Miller, AB; Qin, D; Wu, C; Zhang, Z; Lin, X Furin inhibitors US Patent US11773078 Publication Date 10/3/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Furin [108-574] |
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| Name: | Furin [108-574] |
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| Synonyms: | Furin (108-574) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50656.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 108-574 |
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| Residue: | 467 |
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| Sequence: | DVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNY
DPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRML
DGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGS
IFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQN
EKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLN
ANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEV
RKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADG
FNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTA
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| BDBM621364 |
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| n/a |
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| Name | BDBM621364 |
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| Synonyms: | US11773078, Example 116 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H38BrFN6O4 |
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| Mol. Mass. | 669.584 |
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| SMILES | CC(=O)NCC1CCN(Cc2cc(Oc3ccc(nc3)N3CCN(CCC(O)=O)CC3)nc(c2)-c2cc(F)cc(Br)c2)CC1 |
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| Structure | 
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