| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [L858R,C797S] |
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| Ligand | BDBM625612 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | EGFR kinase Enzymatic Activity Test 1 |
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| IC50 | 180±n/a nM |
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| Citation |  He, P; Dong, G; Zhao, H; Wang, X; Chen, S; Huang, P; Deng, T; Zhang, R; LI, H ARYL PHOSPHOROUS OXIDE COMPOUNDS AND USE THEREOF US Patent US20230322822 Publication Date 10/12/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [L858R,C797S] |
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| Name: | Epidermal growth factor receptor [L858R,C797S] |
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| Synonyms: | EGFR | EGFR_HUMAN | ERBB | ERBB1 | HER1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 134307.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[L858R,C797S] |
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| Residue: | 1210 |
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| Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA
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| BDBM625612 |
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| n/a |
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| Name | BDBM625612 |
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| Synonyms: | US20230322822, Compound 35 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H37BrClFN7O2P |
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| Mol. Mass. | 680.979 |
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| SMILES | COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(Cl)cc1Nc1ncc(Br)c(Nc2ccc(F)cc2P(C)(C)=O)n1 |
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| Structure | 
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