| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 5 |
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| Ligand | BDBM179176 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PRMT5/MEP50 Enzyme Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Duncan, KW; Chesworth, R; Boriack-Sjodin, PA; Munchhof, MJ; Jin, L PRMT5 inhibitors and uses thereof US Patent US9675614 Publication Date 6/13/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 5 |
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| Name: | Protein arginine N-methyltransferase 5 |
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| Synonyms: | Human Flag-PRMT5/6His-MeP50 protein | PRMT5/MeP50 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Protein arginine N-methyltransferase 5 |
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| Synonyms: | ANM5_HUMAN | Flag-PRMT5 | HRMT1L5 | IBP72 | JBP1 | PRMT5 | Protein arginine N-methyltransferase 5 (Flag-PRMT5) | SKB1 |
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| Type: | Protein |
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| Mol. Mass.: | 72548.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Full-length PRMT5 with FLAG tag fused directly to Ala 2 (MDYKDDDDK removed) |
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| Residue: | 636 |
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| Sequence: | AAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKN
RPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPA
FLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSG
EEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKK
GFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFA
KGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVL
MVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMR
EWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLY
NEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFP
VEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVR
FWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
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| Component 2 |
| Name: | Protein arginine N-methyltransferase 5 |
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| Synonyms: | 6His-MEP50 | ANM5_HUMAN | HRMT1L5 | IBP72 | JBP1 | Methylosome protein 50 (6His-MeP50) | PRMT5 | SKB1 |
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| Type: | Protein |
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| Mol. Mass.: | 37539.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Full-length MeP50 with His tag fused directly to Arg 2 of MEP50 |
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| Residue: | 348 |
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| Sequence: | MHHHHHHRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCW
AGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETL
IVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVA
ASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDEN
GTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQ
AHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE
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| BDBM179176 |
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| n/a |
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| Name | BDBM179176 |
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| Synonyms: | US10307413, Compound 241 | US10391089, Compound 241 | US10980794, Cmpd No 241 | US9675614, 241 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N4O2 |
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| Mol. Mass. | 350.4143 |
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| SMILES | O[C@@H](CNC(=O)c1cccc2[nH]cnc12)CN1CCc2ccccc2C1 |r| |
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| Structure | 
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