| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-lysine 6-oxidase |
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| Ligand | BDBM633244 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of LOX and LOXL1-4 |
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| IC50 | >300±n/a nM |
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| Citation |  Findlay, AD; Turner, CI; Deodhar, M; Foot, JS; Jarolimek, W; Schilter Sambade, H; Zhou, W; Perryman, LA BIOPROBES FOR LYSYL OXIDASES AND USES THEREOF US Patent US20230349907 Publication Date 11/2/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-lysine 6-oxidase |
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| Name: | Protein-lysine 6-oxidase |
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| Synonyms: | 1.4.3.13 | LOX | LYOX_BOVIN | Lysyl oxidase | Protein-lysine 6-oxidase | Protein-lysine 6-oxidase, long form | Protein-lysine 6-oxidase, short form |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47015.72 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_118967 |
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| Residue: | 417 |
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| Sequence: | MRFAWTALLGSLQLCALVRCAPPAASHRQPPREQAAAPGAWRQKIQWENNGQVFSLLSLG
SQYQPQRRRDPGATAPGAANATAPQMRTPILLLRNNRTAAARVRTAGPSAAAAGRPRPAA
RHWFQAGYSTSGAHDAGTSRADNQTAPGEVPTLSNLRPPNRVEVDGMVGDDPYNPYKYTD
DNPYYNYYDTYERPRPGSRYRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMAMYNLRCA
AEENCLASSAYRDVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDE
FSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYNADID
CQWIDITDVKPGNYILKVSVNPSYLVPESDYSNNVVRCEIRYTGHHAYASGCTISPY
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| BDBM633244 |
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| n/a |
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| Name | BDBM633244 |
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| Synonyms: | 3-(((Z)-4-amino-2-fluorobut-2-en-1-yl)sulfonyl)-N-(3,5-bis(4-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)piperazine-1-carbonyl)phenyl)benzamide hydrochloride | US20230349907, Compound 1-10 |
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| Type | Small organic molecule |
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| Emp. Form. | C47H61FN10O9S3 |
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| Mol. Mass. | 1025.242 |
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| SMILES | NC\C=C(/F)CS(=O)(=O)c1cccc(c1)C(=O)Nc1cc(cc(c1)C(=O)N1CCN(CC1)C(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)C(=O)N1CCN(CC1)C(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 |r| |
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| Structure | 
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