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TargetProstaglandin E2 receptor EP4 subtype
LigandBDBM639899
Substrate/Competitorn/a
Meas. Tech.hEP4 cAMP Assay
IC50 12.0±n/a nM
Citation Boss, CCorminboeuf, OFretz, HLyothier, IPozzi, DRichard-Bildstein, SSiendt, HSifferlen, T Pyrimidine derivatives as PGE2 receptor modulators US Patent US11839613 Publication Date 12/12/2023
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E2 receptor EP4 subtype
Name:Prostaglandin E2 receptor EP4 subtype
Synonyms:PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:Enzyme
Mol. Mass.:53134.53
Organism:Homo sapiens (Human)
Description:P35408
Residue:488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG
LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA
INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA
HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG
HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP
SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG
QHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG
MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSET
LNLSEKCI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM639899
n/a
NameBDBM639899
Synonyms:3-Ethoxy-5-{6-[2-(4-methyl-benzo[b]thiophen-5-yl)-ethylamino]-pyrimidin-4-yl}- thiophene-2-carboxylic acid | US11839613, Example 20
TypeSmall organic molecule
Emp. Form.C22H21N3O3S2
Mol. Mass.439.55
SMILESCCOc1cc(sc1C(O)=O)-c1cc(NCCc2ccc3sccc3c2C)ncn1
Structure
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