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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Ligand | BDBM643591 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DYRK1A kinase assay | ||
| EC50 | 0.300±n/a nM | ||
| Citation |  Mittapalli, GK; Mak, CC; Turner, LD; Hofilena, BJ; Vakiti, RR; Eastman, BW; Wallace, DM 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF US Patent US20240002391 Publication Date 1/4/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85616.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13627 | ||
| Residue: | 763 | ||
| Sequence: |
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| BDBM643591 | |||
| n/a | |||
| Name | BDBM643591 | ||
| Synonyms: | US20240002391, Compound 719 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H25F2N7O2 | ||
| Mol. Mass. | 445.4657 | ||
| SMILES | COc1nc(N[C@H]2CC[C@H](O)CC2)nn2ccc(-c3ccc(N=N)c(NCC(F)F)c3)c12 |r,wU:9.9,wD:6.5,(-.08,.02,;-1.41,-.77,;-1.4,-2.31,;-.04,-3.19,;-.04,-4.73,;1.29,-5.5,;2.63,-4.73,;3.96,-5.5,;5.3,-4.73,;5.3,-3.19,;6.63,-2.42,;3.96,-2.42,;2.63,-3.19,;-1.37,-5.5,;-2.71,-4.73,;-4.17,-5.21,;-5.08,-3.96,;-4.17,-2.72,;-4.65,-1.25,;-6.15,-.93,;-6.63,.53,;-5.6,1.68,;-6.07,3.14,;-5.04,4.29,;-4.09,1.36,;-3.32,2.69,;-1.79,2.85,;-1.16,4.26,;-2.07,5.5,;.37,4.42,;-3.62,-.11,;-2.71,-3.19,)| | ||
| Structure | 
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