Reaction Details |
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Target | Dual specificity protein kinase CLK2 |
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Ligand | BDBM644484 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biochemical Assay for Inhibitors of CLK2 Kinase Activity Assay |
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IC50 | 78.4±n/a nM |
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Citation | Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Benzo[c][2,6]naphthyridine derivatives, compositions and therapeutic uses thereof US Patent US11866436 Publication Date 1/9/2024 |
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More Info.: | Get all data from this article, Assay Method |
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Dual specificity protein kinase CLK2 |
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Name: | Dual specificity protein kinase CLK2 |
Synonyms: | 2.7.12.1 | CDC-like kinase 2 | CDC-like kinase 2 (CLK2) | CDC2-like kinase 2 (CLK2) | CLK2 | CLK2_HUMAN |
Type: | n/a |
Mol. Mass.: | 60128.79 |
Organism: | Homo sapiens (Human) |
Description: | P49760 |
Residue: | 499 |
Sequence: | MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYD
DRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRR
RRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQC
VDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMC
ISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVN
SDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQ
PCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLD
WDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFA
RLRAEPPNKLWDSSRDISR
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BDBM644484 |
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n/a |
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Name | BDBM644484 |
Synonyms: | 5-(3-(4-((3-(Cyanomethyl)-5-fluorobenzyl)amino)butoxy)azetidin-1-yl)benzo[c][2,6]naphthyridine-8-carboxylic Acid | US11866436, Example 79 |
Type | Small organic molecule |
Emp. Form. | C29H28FN5O3 |
Mol. Mass. | 513.5627 |
SMILES | OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(F)cc(CC#N)c1)c1ccncc21 |
Structure |
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