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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Macrophage migration inhibitory factor | ||
| Ligand | BDBM648293 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | MIF Enzymatic Assay | ||
| IC50 | 18.6±n/a nM | ||
| Citation |  Fan, G; Fong, KC; Yang, H; Wang, J Compounds and their uses as MIF inhibitors US Patent US11884682 Publication Date 1/30/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Macrophage migration inhibitory factor | |||
| Name: | Macrophage migration inhibitory factor | ||
| Synonyms: | GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 12478.18 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P14174 | ||
| Residue: | 115 | ||
| Sequence: |
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| BDBM648293 | |||
| n/a | |||
| Name | BDBM648293 | ||
| Synonyms: | Cis-4-(3-methoxy-4-((5-(thiophen-2- yl)-1,3,4-oxadiazol-2- yl)carbamoyl)phenyl)cyclohexane-1- carboxylic acid | US11884682, Compound 27 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H21N3O5S | ||
| Mol. Mass. | 427.474 | ||
| SMILES | COc1cc(ccc1C(=O)Nc1nnc(o1)-c1cccs1)C1CC[C@@H](CC1)C(O)=O |r,wU:24.30,(-.11,-2.98,;-.51,-1.49,;.58,-.4,;2.07,-.8,;3.16,.29,;2.76,1.78,;1.27,2.18,;.18,1.09,;-1.3,1.49,;-1.7,2.98,;-2.39,.4,;-3.88,.8,;-4.36,2.26,;-5.9,2.26,;-6.37,.8,;-5.13,-.11,;-7.71,.03,;-8.95,.93,;-10.2,.03,;-9.72,-1.44,;-8.18,-1.44,;4.65,-.11,;5.04,-1.59,;6.53,-1.99,;7.62,-.9,;7.22,.58,;5.74,.98,;9.11,-1.3,;10.2,-.21,;9.51,-2.79,)| | ||
| Structure | 
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