Reaction Details | |||
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Target | Bromodomain-containing protein 2 [364-436] | ||
Ligand | BDBM179457 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | FP Competitive Binding Assay (BRD-1F) | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
Ki | 35±21 nM | ||
IC50 | 255±114 nM | ||
Comments | extracted | ||
Citation | Wang, S; Ran, X; Zhao, Y; Yang, C; Liu, L; Bai, L; McEachern, D; Stuckey, J; Meagher, JL; Sun, D; Li, X; Zhou, B; Karatas, H; Luo, R; Chinnaiyan, A; Asangani, IA BET bromodomain inhibitors and therapeutic methods using the same US Patent US9675697 Publication Date 6/13/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Bromodomain-containing protein 2 [364-436] | |||
Name: | Bromodomain-containing protein 2 [364-436] | ||
Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain-containing protein 2 (BRD2)(BD2) | Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2) | KIAA9001 | RING3 | ||
Type: | Protein | ||
Mol. Mass.: | 8615.14 | ||
Organism: | Homo sapiens (Human) | ||
Description: | BD2 (364-436 aa) of P25440 | ||
Residue: | 73 | ||
Sequence: |
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BDBM179457 | |||
n/a | |||
Name | BDBM179457 | ||
Synonyms: | US9675697, Cpd. No. 3 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H19N3O2 | ||
Mol. Mass. | 369.4159 | ||
SMILES | COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3ccccc3)c21 |(-1.12,2.92,;-1.75,1.51,;-.98,.18,;.56,.18,;1.33,-1.16,;.56,-2.49,;-.98,-2.49,;-1.75,-1.16,;-3.29,-1.16,;-4.19,-2.4,;-3.79,-3.89,;-5.65,-1.93,;-5.65,-.39,;-4.19,.09,;-3.79,1.58,;1.6,-3.64,;3,-3.01,;4.41,-3.64,;5.65,-2.73,;5.49,-1.2,;4.09,-.57,;3.69,.92,;4.78,2,;4.38,3.49,;2.89,3.89,;1.8,2.8,;2.2,1.31,;2.84,-1.48,)| | ||
Structure |