Reaction Details | |||
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Target | Bromodomain-containing protein 2 [364-436] | ||
Ligand | BDBM179460 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | FP Competitive Binding Assay (BRD-1F) | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
Ki | <10.00±n/a nM | ||
IC50 | 142±31 nM | ||
Comments | extracted | ||
Citation | Wang, S; Ran, X; Zhao, Y; Yang, C; Liu, L; Bai, L; McEachern, D; Stuckey, J; Meagher, JL; Sun, D; Li, X; Zhou, B; Karatas, H; Luo, R; Chinnaiyan, A; Asangani, IA BET bromodomain inhibitors and therapeutic methods using the same US Patent US9675697 Publication Date 6/13/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Bromodomain-containing protein 2 [364-436] | |||
Name: | Bromodomain-containing protein 2 [364-436] | ||
Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain-containing protein 2 (BRD2)(BD2) | Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2) | KIAA9001 | RING3 | ||
Type: | Protein | ||
Mol. Mass.: | 8615.14 | ||
Organism: | Homo sapiens (Human) | ||
Description: | BD2 (364-436 aa) of P25440 | ||
Residue: | 73 | ||
Sequence: |
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BDBM179460 | |||
n/a | |||
Name | BDBM179460 | ||
Synonyms: | US9675697, Cpd. No. 17 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H20N4O2 | ||
Mol. Mass. | 408.4519 | ||
SMILES | COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c[nH]c4ccccc34)c21 |(-1.88,2.57,;-2.65,1.24,;-1.88,-.09,;-.34,-.09,;.43,-1.43,;-.34,-2.76,;-1.88,-2.76,;-2.65,-1.43,;-4.19,-1.43,;-5.1,-2.67,;-4.7,-4.16,;-6.56,-2.2,;-6.56,-.66,;-5.1,-.18,;-4.7,1.31,;.69,-3.9,;2.09,-3.28,;3.5,-3.9,;4.75,-3,;4.59,-1.47,;3.18,-.84,;2.78,.65,;1.53,1.55,;2.01,3.02,;3.55,3.02,;4.58,4.16,;6.09,3.84,;6.56,2.38,;5.53,1.23,;4.03,1.55,;1.93,-1.75,)| | ||
Structure |