Reaction Details | |||
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Target | Bromodomain-containing protein 2 [91-163] | ||
Ligand | BDBM50092341 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biolayer Interferometry (BLI) Binding Assay | ||
pH | 7.4±n/a | ||
Kd | 34±2.10 nM | ||
Comments | extracted | ||
Citation | Wang, S; Ran, X; Zhao, Y; Yang, C; Liu, L; Bai, L; McEachern, D; Stuckey, J; Meagher, JL; Sun, D; Li, X; Zhou, B; Karatas, H; Luo, R; Chinnaiyan, A; Asangani, IA BET bromodomain inhibitors and therapeutic methods using the same US Patent US9675697 Publication Date 6/13/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Bromodomain-containing protein 2 [91-163] | |||
Name: | Bromodomain-containing protein 2 [91-163] | ||
Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain-containing protein 2 (BRD2)(BD1) | Bromodomain-containing protein 2 Bromo 1 domain(BRD2 BD1) | KIAA9001 | RING3 | ||
Type: | n/a | ||
Mol. Mass.: | 8836.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | BD1 (91-163 aa) of P25440 | ||
Residue: | 73 | ||
Sequence: |
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BDBM50092341 | |||
n/a | |||
Name | BDBM50092341 | ||
Synonyms: | CHEMBL3581660 | US9675697, Cpd. No. 22 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H25N5O2 | ||
Mol. Mass. | 415.4876 | ||
SMILES | CCc1n[nH]c(CC)c1-c1nccc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 |(1.07,4.53,;.13,3.67,;-1.38,4.15,;-1.89,5.66,;-3.48,5.64,;-3.96,4.12,;-5.46,3.6,;-6.42,4.44,;-2.66,3.22,;-2.64,1.63,;-3.92,.87,;-3.92,-.64,;-2.64,-1.4,;-1.3,-.64,;,-1.4,;1.3,-.64,;2.62,-1.4,;3.96,-.64,;5.34,-1.44,;5.49,-3.01,;4.53,-3.86,;7.04,-3.34,;7.84,-1.97,;6.77,-.78,;7.03,.46,;3.96,.87,;5.34,1.67,;5.34,2.95,;2.62,1.63,;1.3,.87,;-1.3,.87,)| | ||
Structure |