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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 3 [326-398] | ||
| Ligand | BDBM50092341 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biolayer Interferometry (BLI) Binding Assay | ||
| pH | 7.4±n/a | ||
| Kd | 19±4.90 nM | ||
| Comments | extracted | ||
| Citation |  Wang, S; Ran, X; Zhao, Y; Yang, C; Liu, L; Bai, L; McEachern, D; Stuckey, J; Meagher, JL; Sun, D; Li, X; Zhou, B; Karatas, H; Luo, R; Chinnaiyan, A; Asangani, IA BET bromodomain inhibitors and therapeutic methods using the same US Patent US9675697 Publication Date 6/13/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 3 [326-398] | |||
| Name: | Bromodomain-containing protein 3 [326-398] | ||
| Synonyms: | BRD3 | BRD3_HUMAN | Bromodomain-containing protein 3 (BRD3)(BD2) | Bromodomain-containing protein 3 Bromo 2 domain(BRD3 BD2) | KIAA0043 | RING3L | ||
| Type: | n/a | ||
| Mol. Mass.: | 8553.07 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | BD2 (326-398 aa) of Q15059 | ||
| Residue: | 73 | ||
| Sequence: |
| ||
| BDBM50092341 | |||
| n/a | |||
| Name | BDBM50092341 | ||
| Synonyms: | CHEMBL3581660 | US9675697, Cpd. No. 22 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H25N5O2 | ||
| Mol. Mass. | 415.4876 | ||
| SMILES | CCc1n[nH]c(CC)c1-c1nccc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 |(1.07,4.53,;.13,3.67,;-1.38,4.15,;-1.89,5.66,;-3.48,5.64,;-3.96,4.12,;-5.46,3.6,;-6.42,4.44,;-2.66,3.22,;-2.64,1.63,;-3.92,.87,;-3.92,-.64,;-2.64,-1.4,;-1.3,-.64,;,-1.4,;1.3,-.64,;2.62,-1.4,;3.96,-.64,;5.34,-1.44,;5.49,-3.01,;4.53,-3.86,;7.04,-3.34,;7.84,-1.97,;6.77,-.78,;7.03,.46,;3.96,.87,;5.34,1.67,;5.34,2.95,;2.62,1.63,;1.3,.87,;-1.3,.87,)| | ||
| Structure | 
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