Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Bromodomain-containing protein 2 [364-436] | ||
Ligand | BDBM50092330 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | FP Competitive Binding Assay (No.350) | ||
Temperature | 298.15±n/a K | ||
Ki | 109±10.00 nM | ||
Comments | extracted | ||
Citation | Wang, S; Ran, X; Zhao, Y; Yang, C; Liu, L; Bai, L; McEachern, D; Stuckey, J; Meagher, JL; Sun, D; Li, X; Zhou, B; Karatas, H; Luo, R; Chinnaiyan, A; Asangani, IA BET bromodomain inhibitors and therapeutic methods using the same US Patent US9675697 Publication Date 6/13/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Bromodomain-containing protein 2 [364-436] | |||
Name: | Bromodomain-containing protein 2 [364-436] | ||
Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain-containing protein 2 (BRD2)(BD2) | Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2) | KIAA9001 | RING3 | ||
Type: | Protein | ||
Mol. Mass.: | 8615.14 | ||
Organism: | Homo sapiens (Human) | ||
Description: | BD2 (364-436 aa) of P25440 | ||
Residue: | 73 | ||
Sequence: |
| ||
BDBM50092330 | |||
n/a | |||
Name | BDBM50092330 | ||
Synonyms: | CHEMBL3581649 | US9675697, RX-3 | ||
Type | Small organic molecule | ||
Emp. Form. | C17H14ClN3O2 | ||
Mol. Mass. | 327.765 | ||
SMILES | COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(Cl)c21 |(5.4,2.98,;5.4,1.69,;4.01,.88,;2.65,1.65,;1.32,.88,;1.32,-.65,;2.65,-1.41,;4.01,-.65,;5.4,-1.46,;5.55,-3.05,;4.58,-3.9,;7.12,-3.38,;7.92,-1.99,;6.85,-.79,;7.11,.47,;,-1.41,;-1.32,-.65,;-2.67,-1.41,;-3.97,-.65,;-3.97,.88,;-2.67,1.65,;-2.68,2.94,;-1.32,.88,)| | ||
Structure |