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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 2 [364-436] | ||
| Ligand | BDBM179633 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | FP Competitive Binding Assay (No.350) | ||
| Temperature | 298.15±n/a K | ||
| Ki | 2.90±n/a nM | ||
| Comments | extracted | ||
| Citation |  Wang, S; Ran, X; Zhao, Y; Yang, C; Liu, L; Bai, L; McEachern, D; Stuckey, J; Meagher, JL; Sun, D; Li, X; Zhou, B; Karatas, H; Luo, R; Chinnaiyan, A; Asangani, IA BET bromodomain inhibitors and therapeutic methods using the same US Patent US9675697 Publication Date 6/13/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 2 [364-436] | |||
| Name: | Bromodomain-containing protein 2 [364-436] | ||
| Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain-containing protein 2 (BRD2)(BD2) | Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2) | KIAA9001 | RING3 | ||
| Type: | Protein | ||
| Mol. Mass.: | 8615.14 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | BD2 (364-436 aa) of P25440 | ||
| Residue: | 73 | ||
| Sequence: |
| ||
| BDBM179633 | |||
| n/a | |||
| Name | BDBM179633 | ||
| Synonyms: | US9675697, Cpd. No. 316 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C33H33N7O3 | ||
| Mol. Mass. | 575.6602 | ||
| SMILES | COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccc(NC(=O)N4CCN(C)CC4)c4ccccc34)c21 |(-1.5,3.22,;-2.13,1.81,;-1.36,.48,;.18,.48,;.95,-.85,;.18,-2.19,;-1.36,-2.19,;-2.13,-.85,;-3.67,-.85,;-4.57,-2.1,;-4.18,-3.59,;-6.04,-1.62,;-6.04,-.08,;-4.57,.39,;-4.18,1.88,;1.21,-3.33,;2.62,-2.71,;4.03,-3.33,;5.27,-2.43,;6.68,-3.05,;5.11,-.9,;3.7,-.27,;3.54,1.26,;2.14,1.89,;1.97,3.42,;3.22,4.33,;3.06,5.86,;1.65,6.48,;.41,5.58,;1.49,8.01,;2.74,8.92,;2.58,10.45,;1.17,11.08,;1.01,12.61,;-.08,10.17,;.09,8.64,;4.63,3.7,;5.87,4.6,;7.28,3.98,;7.44,2.45,;6.2,1.54,;4.79,2.17,;2.46,-1.17,)| | ||
| Structure | 
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