| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [L858R,T790M,C797S] |
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| Ligand | BDBM649440 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TBD |
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| IC50 | <1±n/a nM |
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| Citation |  ZHENG, S; DENG, W; CAMPOS, SA; YANG, Y; TIAN, Z; ZHENG, Q; WU, G; ZHAO, Z; LI, L; FU, J; ZHAO, S TRICYCLIC COMPOUNDS AS EGFR INHIBITORS US Patent US20240034743 Publication Date 2/1/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [L858R,T790M,C797S] |
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| Name: | Epidermal growth factor receptor [L858R,T790M,C797S] |
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| Synonyms: | EGFR | EGFR (L858R, T790M, C797S) | EGFR_HUMAN | ERBB | ERBB1 | HER1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 134337.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[L858R,T790M,C797S] |
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| Residue: | 1210 |
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| Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA
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| BDBM649440 |
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| n/a |
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| Name | BDBM649440 |
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| Synonyms: | US20240034743, Compound 129 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H31BrN10O2 |
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| Mol. Mass. | 643.537 |
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| SMILES | CNC(=O)c1c(Nc2nc(Nc3cc4-c5cnn(C)c5CCN(C(C)C)c4cc3OC)ncc2Br)ccc2nccnc12 |
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| Structure | 
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