| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium release-activated calcium channel protein 1 |
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| Ligand | BDBM652087 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | GFP-NFAT translocation assay |
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| IC50 | 5.01±n/a nM |
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| Citation |  Zhou, Y; He, L Chemical modulators of store-operated calcium channels and their therapeutic applications US Patent US11905244 Publication Date 2/20/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium release-activated calcium channel protein 1 |
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| Name: | Calcium release-activated calcium channel protein 1 |
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| Synonyms: | CRACM1 | CRCM1_HUMAN | Calcium channel (VER) | Calcium release-activated calcium channel | Calcium release-activated calcium channel protein 1 | ORAI1 | Protein orai-1 | TMEM142A | Transmembrane protein 142A |
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| Type: | Protein |
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| Mol. Mass.: | 32676.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96D31 |
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| Residue: | 301 |
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| Sequence: | MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSY
SEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLL
IAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFST
VIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIAST
TIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHY
A
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| BDBM652087 |
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| n/a |
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| Name | BDBM652087 |
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| Synonyms: | US11905244, Compound 106 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26N4O5S2 |
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| Mol. Mass. | 538.638 |
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| SMILES | COc1ccc(cc1)N1C(=O)CC(S\C(NCCc2ccc(cc2)S(N)(=O)=O)=N\c2ccccc2)C1=O |
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| Structure | 
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