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TargetATP-sensitive inward rectifier potassium channel 1
LigandBDBM312693
Substrate/Competitorn/a
Meas. Tech.Electrophysiology Assay
IC50 80.0±n/a nM
Citation Pasternak, ADeJesus, RKDing, FDong, SFrie, JLGu, XJiang, JShahripour, APio, BTang, HWalsh, S Inhibitors of the renal outer medullary potassium channel US Patent US9604998 Publication Date 3/28/2017
More Info.:Get all data from this article,  Assay Method
 
ATP-sensitive inward rectifier potassium channel 1
Name:ATP-sensitive inward rectifier potassium channel 1
Synonyms:ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:Enzyme Catalytic Domain
Mol. Mass.:44809.08
Organism:Homo sapiens (Human)
Description:gi_223460826
Residue:391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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  Blast E-value cutoff:
BDBM312693
n/a
NameBDBM312693
Synonyms:US9604998, Example 92
TypeSmall organic molecule
Emp. Form.C23H25FN8O
Mol. Mass.448.496
SMILESCc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(CCc3ccc(nc3)-n3cnnn3)C[C@H]2CO1 |r|
Structure
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