Reaction Details |
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Target | Nicotinamide phosphoribosyltransferase |
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Ligand | BDBM180921 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biochemical Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 1.00±n/a nM |
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Comments | extracted |
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Citation | Bair, KW; Buckmelter, AJ; Han, B; Lin, J; Reynolds, DJ; Smith, CC; Wang, Z; Zheng, X Compounds and compositions for the inhibition of NAMPT US Patent US9676721 Publication Date 6/13/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Nicotinamide phosphoribosyltransferase |
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Name: | Nicotinamide phosphoribosyltransferase |
Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
Type: | Enzyme |
Mol. Mass.: | 55524.98 |
Organism: | Homo sapiens (Human) |
Description: | P43490 |
Residue: | 491 |
Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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BDBM180921 |
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n/a |
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Name | BDBM180921 |
Synonyms: | US9676721, 79 2-cyano-1-{[4-(1-methyl-1H-indazole-6-sulfonyl)phenyl]methyl}-3-(pyridin-4-yl)guanidine |
Type | Small organic molecule |
Emp. Form. | C22H19N7O2S |
Mol. Mass. | 445.497 |
SMILES | Cn1ncc2ccc(cc12)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1 |
Structure |
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