Reaction Details |
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Target | Caspase-3 |
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Ligand | BDBM10218 |
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Substrate/Competitor | Caspase-3 (7) Fluorogenic Substrate |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 40000±8000 nM |
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Citation | Fattorusso, R; Jung, D; Crowell, KJ; Forino, M; Pellecchia, M Discovery of a novel class of reversible non-peptide caspase inhibitors via a structure-based approach. J Med Chem48:1649-56 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Caspase-3 |
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Name: | Caspase-3 |
Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
Type: | Hydrolase; heterotetramer of two heterodimers |
Mol. Mass.: | 31607.55 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 277 |
Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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BDBM10218 |
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Caspase-3 (7) Fluorogenic Substrate |
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Name: | Caspase-3 (7) Fluorogenic Substrate |
Synonyms: | n/a |
Type: | n/a |
Mol. Mass.: | 1477.75 |
Organism: | n/a |
Description: | AFC = 7-Amino-4-trifluoromethylcoumarin |
Residue: | 16 |
Sequence: | |