Reaction Details |
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Target | MAP kinase-interacting serine/threonine-protein kinase 2 |
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Ligand | BDBM168221 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Mnk Biochemical Enzymatic Assay |
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Temperature | 298.15±n/a K |
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IC50 | <10.00±n/a nM |
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Comments | extracted |
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Citation | Reich, SH; Sprengeler, PA; Webber, SE; Xiang, AX; Ernst, JT MNK inhibitors and methods related thereto US Patent US9669031 Publication Date 6/6/2017 |
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More Info.: | Get all data from this article, Assay Method |
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MAP kinase-interacting serine/threonine-protein kinase 2 |
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Name: | MAP kinase-interacting serine/threonine-protein kinase 2 |
Synonyms: | GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2 |
Type: | Protein |
Mol. Mass.: | 51870.79 |
Organism: | Homo sapiens (Human) |
Description: | Q9HBH9 |
Residue: | 465 |
Sequence: | MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
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BDBM168221 |
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n/a |
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Name | BDBM168221 |
Synonyms: | US9669031, 50 N-[6-[(8-chloro-4′,4′-difluoro-1,5-dioxo-spiro[2H-imidazo[1,5-a]pyridine-3,1′-cyclohexane]-6-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamide (Cpd. No. 50) | US9669031, 99 6-[(6-aminopyrimidin-4-yl)amino]-8-chloro-4′,4′-difluoro-spiro[2H-imidazo[1,5-a]pyridine-3,1′-cyclohexane]-1,5-dione hydrochloride (Cpd. No. 99) |
Type | Small organic molecule |
Emp. Form. | C20H19ClF2N6O3 |
Mol. Mass. | 464.853 |
SMILES | FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21 |
Structure |
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