Reaction Details |
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Target | Cholinesterase |
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Ligand | BDBM10629 |
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Substrate/Competitor | BDBM8978 |
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Meas. Tech. | Cholinesterase Inhibition Assay |
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IC50 | 23±n/a nM |
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Citation | Luo, W; Yu, QS; Kulkarni, SS; Parrish, DA; Holloway, HW; Tweedie, D; Shafferman, A; Lahiri, DK; Brossi, A; Greig, NH Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J Med Chem49:2174-85 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Cholinesterase |
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Name: | Cholinesterase |
Synonyms: | Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase |
Type: | Homotetramer |
Mol. Mass.: | 68422.27 |
Organism: | Homo sapiens (Human) |
Description: | P06276 |
Residue: | 602 |
Sequence: | MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
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BDBM10629 |
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BDBM8978 |
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Name | BDBM10629 |
Synonyms: | (+)-(3aR)-3a,8-Dimethyl-2,3,3a,8a-tetrahydrofuro[2,3-b]indol-5-yl N-(4-Isopropylphenyl)carbamate | (3aR)-3a,8-dimethyl-2H,3H,3aH,8H,8aH-furo[2,3-b]indol-5-yl N-[4-(propan-2-yl)phenyl]carbamate | Physovenine Carbamate 23b |
Type | Small organic molecule |
Emp. Form. | C22H26N2O3 |
Mol. Mass. | 366.4534 |
SMILES | CC(C)c1ccc(NC(=O)Oc2ccc3N(C)C4OCC[C@]4(C)c3c2)cc1 |r| |
Structure |
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