| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
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| Ligand | BDBM314618 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Receptor Radioligand Binding Assay |
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| Ki | 2.00±n/a nM |
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| Citation |  Shireman, BT; Lebold, TP; Dvorak, CA; Coate, HR; Ziff, JM; Preville, C; Gelin, C; Chen, G Substituted 2-azabicycles and their use as orexin receptor modulators US Patent US9611262 Publication Date 4/4/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin/Hypocretin receptor type 1 |
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| Name: | Orexin/Hypocretin receptor type 1 |
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| Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
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| Type: | Protein |
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| Mol. Mass.: | 47554.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43613 |
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| Residue: | 425 |
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| Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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| BDBM314618 |
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| n/a |
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| Name | BDBM314618 |
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| Synonyms: | US9611262, Example 122 | US9611262, Example 196 | [(1R,2R,4S,5R)-5-[(5-chloro-2-pyridyl)oxy]-2-methyl-3-azabicyclo[2.2.1]heptan-3-yl]-[6-methyl-3-(triazol-2-yl)-2-pyridyl]methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21ClN6O2 |
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| Mol. Mass. | 424.883 |
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| SMILES | CC1C2CC(Oc3ccc(Cl)cn3)C(C2)N1C(=O)c1nc(C)ccc1-n1nccn1 |TLB:16:15:4.3:14,THB:5:4:15.1:14,0:1:4.3:14| |
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| Structure | 
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