| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Myeloperoxidase |
|---|
| Ligand | BDBM312171 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibitory Activity |
|---|
| IC50 | 7.00±n/a nM |
|---|
| Citation |  Inghardt, TB; Johannesson, P; Jurva, U; Lindstedt-Alstermark, E; Tomkinson, N; Stonehouse, JP 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase US Patent US9616063 Publication Date 4/11/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Myeloperoxidase |
|---|
| Name: | Myeloperoxidase |
|---|
| Synonyms: | 84 kDa myeloperoxidase | 89 kDa myeloperoxidase | MPO | Mpo protein | Myeloperoxidase | Myeloperoxidase (MPO) | Myeloperoxidase heavy chain | Myeloperoxidase light chain | PERM_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 83888.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P05164 |
|---|
| Residue: | 745 |
|---|
| Sequence: | MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS
LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH
VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC
NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD
QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND
PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL
GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL
REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR
SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE
GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN
AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL
LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS
NSYPRDFVNCSTLPALNLASWREAS
|
|
|
|---|
| BDBM312171 |
|---|
| n/a |
|---|
| Name | BDBM312171 |
|---|
| Synonyms: | 1-[2-(1-Aminoethyl)-4-chlorobenzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | US10016430, Example 2 | US11000525, Example 2 | US9616063, 2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H15ClN4OS |
|---|
| Mol. Mass. | 334.824 |
|---|
| SMILES | CC(N)c1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S |$;;;;;;;;;;;;;;;HN;;;;;;$| |
|---|
| Structure | 
|
|---|
Search and Browse
