Reaction Details |
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Target | Thyroid peroxidase |
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Ligand | BDBM312257 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibitory Activity |
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IC50 | 19000±n/a nM |
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Citation | Inghardt, TB; Johannesson, P; Jurva, U; Lindstedt-Alstermark, E; Tomkinson, N; Stonehouse, JP 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase US Patent US9616063 Publication Date 4/11/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Thyroid peroxidase |
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Name: | Thyroid peroxidase |
Synonyms: | PERT_HUMAN | TPO | Thyroid peroxidase | Thyroid peroxidase (TPO) |
Type: | Enzyme |
Mol. Mass.: | 102965.07 |
Organism: | Homo sapiens (Human) |
Description: | P07202 |
Residue: | 933 |
Sequence: | MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR
NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS
EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV
YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD
IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD
QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG
RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA
LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT
VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR
GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL
PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ
MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES
CDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL
TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD
SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ
AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL
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BDBM312257 |
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n/a |
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Name | BDBM312257 |
Synonyms: | 1-{2-[(Cyclopentylamino)methyl]benzyl}-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | US10016430, Example 11 | US11000525, Example 11 | US9616063, 11 |
Type | Small organic molecule |
Emp. Form. | C19H22N4OS |
Mol. Mass. | 354.469 |
SMILES | O=c1[nH]c(=S)n(Cc2ccccc2CNC2CCCC2)c2cc[nH]c12 |$;;;;;;;;;;;;;;HN;;;;;;;;;HN;$| |
Structure |
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