Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Lysine-specific histone demethylase 1A | ||
| Ligand | BDBM183458 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | LSD1 Assays | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 19±n/a nM | ||
| Comments | extracted | ||
| Citation |  Ortega Muñoz, A; Fyfe, MC; Martinell Pedemonte, M; Estiarte Martinez, M; Valls Vidal, N; Kurz, G; Castro Palomino Laria, JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent US9670136 Publication Date 6/6/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Lysine-specific histone demethylase 1A | |||
| Name: | Lysine-specific histone demethylase 1A | ||
| Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 92901.01 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60341 | ||
| Residue: | 852 | ||
| Sequence: |
| ||
| BDBM183458 | |||
| n/a | |||
| Name | BDBM183458 | ||
| Synonyms: | US9670136, 52 N-(4′-((trans)-2-((4-aminocyclohexyl)amino)cyclopropyl)-[1,1′-biphenyl]-3-yl)piperazine-1-sulfonamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H35N5O2S | ||
| Mol. Mass. | 469.643 | ||
| SMILES | NC1CCC(CC1)NC1C[C@@H]1c1ccc(cc1)-c1cccc(NS(=O)(=O)N2CCNCC2)c1 |r,wU:10.12,(11.44,3.85,;10.11,3.08,;10.11,1.54,;8.77,.77,;7.44,1.54,;7.44,3.08,;8.77,3.85,;6.1,.77,;4.77,1.54,;4,2.87,;3.23,1.54,;1.9,.77,;1.9,-.77,;.56,-1.54,;-.77,-.77,;-.77,.77,;.56,1.54,;-2.1,-1.54,;-2.1,-3.08,;-3.44,-3.85,;-4.77,-3.08,;-4.77,-1.54,;-6.1,-.77,;-7.44,-1.54,;-8.21,-2.87,;-6.67,-2.87,;-8.77,-.77,;-8.77,.77,;-10.11,1.54,;-11.44,.77,;-11.44,-.77,;-10.11,-1.54,;-3.44,-.77,)| | ||
| Structure | 
| ||