Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Lysine-specific histone demethylase 1A | ||
Ligand | BDBM254598 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | LSD1 Assays | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 12±n/a nM | ||
Comments | extracted | ||
Citation | Ortega Muñoz, A; Fyfe, MC; Martinell Pedemonte, M; Estiarte Martinez, M; Valls Vidal, N; Kurz, G; Castro Palomino Laria, JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent US9670136 Publication Date 6/6/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Lysine-specific histone demethylase 1A | |||
Name: | Lysine-specific histone demethylase 1A | ||
Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) | ||
Type: | Enzyme | ||
Mol. Mass.: | 92901.01 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60341 | ||
Residue: | 852 | ||
Sequence: |
| ||
BDBM254598 | |||
n/a | |||
Name | BDBM254598 | ||
Synonyms: | US10214477, Example 57 | US9469597, 57 | US9670136, 57 N1-((trans)-2-(4-((2-fluorobenzyl)oxy)phenyl)cyclopropyl)cyclohexane-1,4-diamine | ||
Type | Small organic molecule | ||
Emp. Form. | C22H27FN2O | ||
Mol. Mass. | 354.461 | ||
SMILES | NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(OCc2ccccc2F)cc1 |r,wU:10.12,wD:8.8,(9.44,3.85,;8.11,3.08,;8.11,1.54,;6.77,.77,;5.44,1.54,;5.44,3.08,;6.77,3.85,;4.1,.77,;2.77,1.54,;2,2.87,;1.23,1.54,;-.1,.77,;-.1,-.77,;-1.44,-1.54,;-2.77,-.77,;-4.1,-1.54,;-5.44,-.77,;-6.77,-1.54,;-8.11,-.77,;-9.44,-1.54,;-9.44,-3.08,;-8.11,-3.85,;-6.77,-3.08,;-5.44,-3.85,;-2.77,.77,;-1.44,1.54,)| | ||
Structure |