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TargetChitinase Mutant (T138A)
LigandBDBM10853
Substrate/CompetitorBDBM10852
Meas. Tech.Enzyme Inhibition Assay
Kd 1210±n/a nM
Citation Rao FVHouston DRBoot RGAerts JMHodkinson MAdams DJShiomi KOmura Svan Aalten DM Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases. Chem Biol 12:65-76 (2005) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Chitinase Mutant (T138A)
Name:Chitinase Mutant (T138A)
Synonyms:AfChiB1(T138A) | Class V chitinase ChiB1mutant T138A
Type:Enzyme
Mol. Mass.:47582.95
Organism:Aspergillus fumigatus
Description:n/a
Residue:433
Sequence:
MRFATSTIVKVALLLSSLCVDAAVMWNRDTSSTDLEARASSGYRSVVYFVNWAIYGRNHN
PQDLPVERLTHVLYAFANVRPETGEVYMTDSWADIEKHYPGDSWSDTGNNVYGCIKQLYL
LKKQNRNLKVLLSIGGWAYSPNFAPAASTDAGRKNFAKTAVKLLQDLGFDGLDIDWEYPE
NDQQANDFVLLLKEVRTALDSYSAANAGGQHFLLTVASPAGPDKIKVLHLKDMDQQLDFW
NLMAYDYAGSFSSLSGHQANVYNDTSNPLSTPFNTQTALDLYRAGGVPANKIVLGMPLYG
RSFANTDGPGKPYNGVGQGSWENGVWDYKALPQAGATEHVLPDIMASYSYDATNKFLISY
DNPQVANLKSGYIKSLGLGGAMWWDSSSDKTGSDSLITTVVNALGGTGVFEQSQNELDYP
VSQYDNLRNGMQT
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  Blast E-value cutoff:
BDBM10853
BDBM10852
NameBDBM10853
Synonyms:(2R,5S,8S,11S,15S)-8-benzyl-2,7-dimethyl-5-[3-({[(methylcarbamoyl)amino]methanimidoyl}amino)propyl]-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentaazacycloheptadecane-11,15-dicarboxylic acid | Argifin
TypeSmall organic molecule
Emp. Form.C29H41N9O10
Mol. Mass.675.6901
SMILESCNC(=O)NC(=N)NCCC[C@@H]1NC(=O)[C@@H](C)NC(=O)C[C@H](NC(=O)C[C@H](NC(=O)[C@H](Cc2ccccc2)N(C)C1=O)C(O)=O)C(O)=O |r|
Structure
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