| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] A |
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| Ligand | BDBM10994 |
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| Substrate/Competitor | BDBM10990 |
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| Meas. Tech. | MAO A and MAO B Activity Measurements |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 2000±n/a nM |
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| Citation |  Binda, C; Hubalek, F; Li, M; Herzig, Y; Sterling, J; Edmondson, DE; Mattevi, A Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis. J Med Chem48:8148-54 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Amine oxidase [flavin-containing] A |
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| Name: | Amine oxidase [flavin-containing] A |
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| Synonyms: | AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA) |
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| Type: | Protein |
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| Mol. Mass.: | 59689.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21397 |
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| Residue: | 527 |
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| Sequence: | MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHV
DYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKL
NHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADR
LAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKD
VPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
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| BDBM10994 |
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| BDBM10990 |
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| Name | BDBM10994 |
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| Synonyms: | (1R)-1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-4-ol | 4-hydroxy-N-propargyl-1(R)-aminoindan | R-4HPAI | rasagiline analog |
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| Type | Small organic molecule |
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| Emp. Form. | C12H13NO |
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| Mol. Mass. | 187.2377 |
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| SMILES | Oc1cccc2[C@@H](CCc12)NCC#C |r| |
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| Structure | 
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