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TargetAmine oxidase [flavin-containing] B
LigandBDBM10774
Substrate/CompetitorBDBM10999
Meas. Tech.MAO A and MAO B Activity Measurements
pH7.5±n/a
Temperature298.15±n/a K
Ki 137000±n/a nM
Citation Binda, C; Hubalek, F; Li, M; Herzig, Y; Sterling, J; Edmondson, DE; Mattevi, A Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis. J Med Chem48:8148-54 (2005) [PubMed]  Article
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Amine oxidase [flavin-containing] B
Name:Amine oxidase [flavin-containing] B
Synonyms:AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:Protein
Mol. Mass.:58768.76
Organism:Homo sapiens (Human)
Description:P27338
Residue:520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWR
TMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ
TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVY
YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEER
LKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT
FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
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BDBM10774
BDBM10999
NameBDBM10774
Synonyms:(3R)-3-[methyl(prop-2-yn-1-yl)amino]-2,3-dihydro-1H-inden-5-yl N-ethyl-N-methylcarbamate | 6-(N-methyl-N-ethyl-carbamoyloxy)-N-methyl-N-propargyl--1(R)-aminoindan | Aminoindan deriv. (R)19b | N-propargylaminoindan (R)19b | R-M6CPAI | rasagiline analog
TypeSmall organic molecule
Emp. Form.C17H22N2O2
Mol. Mass.286.3688
SMILESCCN(C)C(=O)Oc1ccc2CC[C@@H](N(C)CC#C)c2c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: