| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 9 |
|---|
| Ligand | BDBM11043 |
|---|
| Substrate/Competitor | BDBM10856 |
|---|
| Meas. Tech. | CA Inhibition Assay |
|---|
| Ki | 15±n/a nM |
|---|
| Citation |  De Simone, G; Vitale, RM; Di Fiore, A; Pedone, C; Scozzafava, A; Montero, JL; Winum, JY; Supuran, CT Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX. J Med Chem49:5544-51 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Carbonic anhydrase 9 |
|---|
| Name: | Carbonic anhydrase 9 |
|---|
| Synonyms: | CA-IX | CA9 | CAH9_HUMAN | Carbonate dehydratase IX | Carbonic anhydrase 9 (CA IX) | Carbonic anhydrase 9 (CAIX) | Carbonic anhydrase 9 precursor | Carbonic anhydrase IX (CA IX) | Carbonic anhydrase IX (CAIX) | Carbonic anhydrases IX | Carbonic anhydrases; II & IX | G250 | MN | Membrane antigen MN | RCC-associated antigen G250 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49669.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Catalytic domain of human cloned isozyme was used in the assay |
|---|
| Residue: | 459 |
|---|
| Sequence: | MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL
GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG
DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL
ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT
VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA
EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS
DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF
GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
|
|
|
|---|
| BDBM11043 |
|---|
| BDBM10856 |
|---|
| Name | BDBM11043 |
|---|
| Synonyms: | N-(2-fluoro-4-sulfamoylphenyl)-3-sulfanylpropanamide | reduced monomeric thio of compound 2b | reduced thio H2b |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H11FN2O3S2 |
|---|
| Mol. Mass. | 278.324 |
|---|
| SMILES | NS(=O)(=O)c1ccc(NC(=O)CCS)c(F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
