Reaction Details |
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Target | Endothelial lipase |
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Ligand | BDBM319483 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biological Activity |
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IC50 | 1.000±n/a nM |
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Citation | Johnson, JA; Pi, Z; Qiao, JX; Kim, S; Wang, TC; Jiang, J; Finlay, H; Lloyd, J Sulfone amide linked benzothiazole inhibitors of endothelial lipase US Patent US10173991 Publication Date 1/8/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Endothelial lipase |
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Name: | Endothelial lipase |
Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
Type: | Protein |
Mol. Mass.: | 56805.62 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y5X9 |
Residue: | 500 |
Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
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BDBM319483 |
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n/a |
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Name | BDBM319483 |
Synonyms: | US10173991, Example 539 | propan-2-yl N-{4- [2-({[(cyclopropyl- carbamoyl)methyl] carbamoyl} (methanesulfonyl) methyl)-5-fluoro- 1,3-benzothiazol- 6-yl]phenyl} carbamate |
Type | Small organic molecule |
Emp. Form. | C25H27FN4O7S2 |
Mol. Mass. | 578.633 |
SMILES | CC(C)OC(=O)Nc1ccc(cc1)-c1cc2sc(nc2cc1F)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CO |
Structure |
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