Ki Summary

Reaction Details

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Target

Ketohexokinase

Ligand

BDBM319583

Substrate/Competitor

n/a

Meas. Tech.

KHK Assay C

IC50

3.60±n/a nM

Citation

Dowling M; Fernando D; Futatsugi K; Huard K; Magee TV; Raymer B; Shavnya A; Smith A; Thuma B; Tsai A; Tu M Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors US Patent US10174007 Publication Date 1/8/2019

More Info.:

Get all data from this article, Assay Method

Ketohexokinase

Name:

Ketohexokinase

Synonyms:

Hepatic fructokinase | Ketohexokinase (KHK)

Type:

Enzyme

Mol. Mass.:

32521.64

Organism:

Homo sapiens (Human)

Description:

P50053

Residue:

298

Sequence:

MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFM
GSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDV
SATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELF
QLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLL
HSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV

BDBM319583

n/a

Name

BDBM319583

Synonyms:

US10174007, Example 2

Type

Small organic molecule

Emp. Form.

C18H18ClF3N4O3

Mol. Mass.

430.809

SMILES

C[C@H]1[C@H](O)CN1c1nc(N2C[C@H]3[C@H](CC(O)=O)[C@H]3C2)c(Cl)c(c1C#N)C(F)(F)F |r|

Structure