| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ketohexokinase |
|---|
| Ligand | BDBM319601 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | KHK Assay B |
|---|
| IC50 | 3.70±n/a nM |
|---|
| Citation |  Dowling M; Fernando D; Futatsugi K; Huard K; Magee TV; Raymer B; Shavnya A; Smith A; Thuma B; Tsai A; Tu M Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors US Patent US10174007 Publication Date 1/8/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ketohexokinase |
|---|
| Name: | Ketohexokinase |
|---|
| Synonyms: | Hepatic fructokinase | Ketohexokinase (KHK) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 32521.64 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P50053 |
|---|
| Residue: | 298 |
|---|
| Sequence: | MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFM
GSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDV
SATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELF
QLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLL
HSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
|
|
|
|---|
| BDBM319601 |
|---|
| n/a |
|---|
| Name | BDBM319601 |
|---|
| Synonyms: | US10174007, Example 40 | [(1R,5S,6R)-3-{5-chloro-6-(difluoromethyl)-2-[(2S)-2-methylazetidin-1-yl]pyrimidin-4-yl}-3-azabicyclo[3.1.0]hex-6-yl]acetic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H19ClF2N4O2 |
|---|
| Mol. Mass. | 372.797 |
|---|
| SMILES | C[C@H]1CCN1c1nc(C(F)F)c(Cl)c(n1)N1C[C@H]2[C@H](CC(O)=O)[C@H]2C1 |
|---|
| Structure | 
|
|---|
Search and Browse
