| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 4 |
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| Ligand | BDBM11340 |
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| Substrate/Competitor | BDBM11326 |
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| Meas. Tech. | Carbonic Anhydrase Enzyme Inhibition Assay |
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| Ki | 38±n/a nM |
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| Citation |  Scozzafava, A; Supuran, CT Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. J Med Chem43:3677-87 (2000) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Carbonic anhydrase 4 |
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| Name: | Carbonic anhydrase 4 |
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| Synonyms: | CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 35152.74 |
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| Organism: | Bos taurus (bovine) |
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| Description: | Bovine isozyme, isolated from lung microsomes |
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| Residue: | 312 |
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| Sequence: | MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAK
TQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSR
AMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQ
PLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQK
PIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLA
PVLACLTVGFLR
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| BDBM11340 |
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| BDBM11326 |
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| Name | BDBM11340 |
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| Synonyms: | Hydroxamate 21 | N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3-methylbutanamide |
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| Type | Small organic molecule |
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| Emp. Form. | C12H18N2O5S |
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| Mol. Mass. | 302.347 |
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| SMILES | COc1ccc(cc1)S(=O)(=O)NC(C(C)C)C(=O)NO |
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| Structure | 
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