| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM11404 |
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| Substrate/Competitor | BDBM11402 |
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| Meas. Tech. | In vitro binding of inhibitor to hCA-II |
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| pH | 7.4±n/a |
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| Temperature | 310.15±n/a K |
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| Ki | 0.08±0.01 nM |
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| Citation |  Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA 2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: synthesis, carbonic anhydrase inhibition and evaluation in the rabbit. Bioorg Med Chem8:957-75 (2000) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM11404 |
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| BDBM11402 |
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| Name | BDBM11404 |
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| Synonyms: | 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 7 | 3-{[(2-methoxyethyl)(3-methoxypropyl)amino]methyl}-2-methyl-1,1-dioxo-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide hydrochloride | 3-{[(2-methoxyethyl)(3-methoxypropyl)amino]methyl}-2-methyl-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride | Compound 17a3 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H25N3O6S3 |
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| Mol. Mass. | 439.571 |
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| SMILES | COCCCN(CCOC)CC1=Cc2cc(sc2S(=O)(=O)N1C)S(N)(=O)=O |t:11| |
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| Structure | 
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