Reaction Details |
| Report a problem with these data |
Target | Carbonic anhydrase 2 |
---|
Ligand | BDBM11407 |
---|
Substrate/Competitor | BDBM11402 |
---|
Meas. Tech. | In vitro binding of inhibitor to hCA-II |
---|
Ki | 0.15±n/a nM |
---|
Citation | Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA 2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: synthesis, carbonic anhydrase inhibition and evaluation in the rabbit. Bioorg Med Chem8:957-75 (2000) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Carbonic anhydrase 2 |
---|
Name: | Carbonic anhydrase 2 |
Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
Type: | Enzyme |
Mol. Mass.: | 29250.71 |
Organism: | Homo sapiens (Human) |
Description: | P00918 |
Residue: | 260 |
Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
|
|
|
BDBM11407 |
---|
BDBM11402 |
---|
Name | BDBM11407 |
Synonyms: | 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 14 | 3-[[Bis(2-methoxyethyl)amino]methyl]-2-propyl-2H-thieno-[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride | 3-{[bis(2-methoxyethyl)amino]methyl}-1,1-dioxo-2-propyl-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide hydrochloride | Compound 17c2 |
Type | Small organic molecule |
Emp. Form. | C16H27N3O6S3 |
Mol. Mass. | 453.597 |
SMILES | CCCN1C(CN(CCOC)CCOC)=Cc2cc(sc2S1(=O)=O)S(N)(=O)=O |c:14| |
Structure |
|